中国动脉硬化杂志2012，Vol.20Issue(11)：1007-1012,6.
瘦素受体基因多态性与云南地区高血压合并肥胖的相关性
Study on the Relationship Between Leptin Receptor Gene Polymorphism and Patients of Hypertension with Obesity in Yunnan Area
王先梅 1李春城 2杨丽霞1
作者信息
- 1. 成都军区昆明总医院心血管内科,云南省昆明市650032
- 2. 昆明医学院研究生院,云南省昆明市650031
- 折叠
摘要
Abstract
Aim To discuss the correlation between leptin receptor (LEPR) gene polymorphism and patients of the Han nationality who suffer from hypertension and obesity in Yunnan region. Methods Select 283 hospitalized pa-
tients of the Han nationality who suffer from hypertension and obesity in yunnan region as hypertension group and select 153 healthy persons of the Han nationality as normal control group at the same time. According to body mass index ( BMI) ≥ 28 kg/m2, the hypertension group is divided into a group of 162 patients suffering from hypertension and obesity and a group of 121 patients suffering from hypertension but without obesity. Use polymerase even response-restriction fragment length polymorphism (PCR - RELP) method for determining Gln223Arg and Lysl09Arg LEPR gene polymorphism, ELISA determination leptin levels in blood. Carotid intima-media thickness (CIMT) were measured by ultrasonography in all subjects. Results The data of genotype frequency of Gln223Arg variant in leptin receptor gene between the case group and the control group had a significant difference ( P < 0. 01 ). The data of genotype frequency of Lysl09Arg variant in leptin receptor gene between the case group and the control group had no significant difference. Gln223Arg alleles LEPR gene frequency of A showed significant difference between the patients of hypertension with obesity and the patients of hypertension without obesity (P < 0. 01). And patients of hypertension with obesity group has a higher CIMT( P < 0. 05). LEPR gene Lysl09Arg frequency showed no significant difference between the patients of hypertension with obesity and the patients of hypertension without obesity (P = 0. 226). Conclusion LEPR gene polymorphism Gln223 Arg was possibly associated with hypertension complicated with obesity in Han population in Yunnan area. And A allele is the risk factor to atherosclerosis in the patients of hypertension with obesity group.
关键词
瘦素受体/基因多态性/肥胖/高血压/颈动脉内膜中膜厚度Key words
Leptin Receptor/ Gene polymorphism/ Obesity/ Hypertension/ Carotid Intima-Media Thickness分类
医药卫生引用本文复制引用
王先梅,李春城,杨丽霞..瘦素受体基因多态性与云南地区高血压合并肥胖的相关性[J].中国动脉硬化杂志,2012,20(11):1007-1012,6.
