中国动脉硬化杂志2012，Vol.20Issue(12)：1064-1068,5.
血管内皮细胞损伤在脓毒症大鼠心肌损伤中的作用
Role of Vascular Endothelial Cell Damage in Myocardial Injury in Septic Rats
摘要
Abstract
Aim To investigate the role of endothelial damage related to septic myocardial injury. Methods 30 Sprague-Dawley rats were divided into 3 groups; sham-operation group, sepsis group and ulinastatin grouo. Plasma von Willebrand factor (vWF) and thrombomodulin (TM) levels were detected with ELISA, plasma creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) levels with reflotron plus clinical chemistry analyser, left ventricular pressure (LVP) , the maximum and minimum rates of LVP change ( + dp/dtmax and - dp/dtmax) by cardiac cathete rization and brain natriuretic peptide ( BNP) levels by Western blot. Results Plasma CK, CK-MB and cardiac BNP levels were elevated, LVP, + dp/dtmax and - dp/dtmax decreased as vWF and TM levels increased in sepsis group compared with those in sham-operation group. However, reduced myocardial injury and improved cardiac function were observed in ulinastatin group. Conclusion Endothelial damage in coronary probably contributes to sepsis induced myocardial injury.关键词
血管内皮细胞损伤/脓毒症/心肌损伤/乌司他丁Key words
Vascular Endothelial Cell Damage/ Sepsis/ Myocardial Injury/ Ulinastatin分类
医药卫生引用本文复制引用
徐秋林,刘静贤,郭晓华,刘志峰,唐柚青,刘云松,苏磊..血管内皮细胞损伤在脓毒症大鼠心肌损伤中的作用[J].中国动脉硬化杂志,2012,20(12):1064-1068,5.基金项目
国家自然科学基金项目资助(81071529) （81071529）
广东省自然科学基金项目资助(9151001002000021.2009,01-2012,12) （9151001002000021.2009,01-2012,12）
