中国肺癌杂志2012，Vol.15Issue(11)：656-662,7.DOI:10.3779/j.issn.1009-3419.2012.11.09
新生淋巴管及其受侵对非小细胞肺癌的预后价值
Prognostic Value of Lymphangeogenesis and Lymphatic Vessel Invasion in Non-small Cell Lung Cancer
胡忠吾 1王文利 2张杰 1毛锋 3申屠阳4
作者信息
- 1. 200030上海,上海交通大学附属胸科医院/上海市肺部肿瘤临床医学中心胸外科
- 2. 223300淮安,南京医科大学附属淮安医院胸外科
- 3. 200065上海,同济大学附属同济医院心胸外科
- 4. 200030上海,上海交通大学附属胸科医院/上海市肺部肿瘤临床医学中心病理科
- 折叠
摘要
Abstract
Background and objective Studies have shown that tumor metastasis in a variety of tumors is associated with lymphangiogenesis and lymphatic vessel invasion (LVl). Tumor metastasis is an important factor that affects the prognosis of patients. The aim of this study is to determine the prognostic value of lymphangiogenesis and LVl in non-small cell lung cancer (NSCLC). Methods We marked the endothelial cells of lymph vessels in lymphangiogenesis with specific monoclonal antibody D2-40. Immunohistochemistry was used to detect the expression of lymphangiogenesis and LVl in 79 cases of stage I-1II NSCLC. Results The intratumoral lymphatic vessel density (ITLVD) was significantly higher in patients with N2 disease than those with NO disease (P=0.01S). The ITLVD was significantly higher in patients with LVI+ than that in those with LVl- (P=0.009). The ITLVD was also remarkably higher in poorly differentiated tumors than that in highly differentiated ones (P=0.007). The ITLVD was remarkably higher in adenocarcinoma than that in squamous cell carcinomas (P=0.025). Kaplan-Meier revealed that the survival rates of patients with higher ITLVD were remarkably poorer than those with lower ITLVD (P=0.007). Thus, the ITLVD is an important prognostic factor of NSCLC. The peritumoral lymphatic vessel density is not correlated with the prognosis. Conclusion The ITLVD level is an important prognostic factor of NSCLC.
关键词
肺肿瘤/新生淋巴管/淋巴管受侵/预后Key words
Lung neoplasms/Lymphangiogenesis/Lymphatic vessel invasion/Prognosis分类
医药卫生引用本文复制引用
胡忠吾,王文利,张杰,毛锋,申屠阳..新生淋巴管及其受侵对非小细胞肺癌的预后价值[J].中国肺癌杂志,2012,15(11):656-662,7.
