中国科学院研究生院学报2012，Vol.29Issue(6)：841-846,6.
氧杂蒽酮对脂肪酸合酶的抑制作用及构效分析
Structure-activity relationship study on inhibition of fatty acid synthase by xanthones
摘要
Abstract
Fatty acid synthase (FAS) , an important enzyme catalyzing the synthesis of long-chain fatty acid in vivo, has been reported to be a potential target for treatment of obesity. We found that xanthones with different functional groups and substituents have different inhibition activities on FAS, and the IC50 values range from 1. 24 μmol/L to 1000 μmol/L and above. Structure-activity relationships for these compounds were then analyzed, and some structure-activity rules were established.关键词
脂肪酸合酶/氧杂蒽酮/抑制剂/构效分析Key words
fatty acid synthase/ xanthones/ inhibitors/ structure-activity analysis分类
医药卫生引用本文复制引用
权小芳,马晓丰..氧杂蒽酮对脂肪酸合酶的抑制作用及构效分析[J].中国科学院研究生院学报,2012,29(6):841-846,6.基金项目
中国科学院生命科学领域优秀青年科技专项基金(KSCX2-EW-Q-19)、生命科学领域"十二五"基础前沿专项(KSCX2-EW-J-21)、王宽诚教育基金和中国科学院研究生院院长基金(095101PY00)资助 （KSCX2-EW-Q-19）
