中国临床药理学与治疗学2012，Vol.17Issue(10)：1087-1090,4.
唐古特大黄多糖组分1对电离辐射损伤小鼠造血系统的影响
Protective effects of purified fraction 1 of polysaccharide extracted from rheum tanguticum on radiation-induced hematopoietic damage in mice
摘要
Abstract
AIM: To study the protective effects of purified fraction 1 of polysaccharide extracted from rheum tanguticum (RTP1) on radiation-induced hematopoietic damage in mice. METHODS: Male Kunming mice which were 6 week old were randomly divided into five groups: normal group (NC) , irradiation control group (IC), RTP1 low dose group (200 mg/ kg), middle dose group (400 mg/kg) and high dose group (800 mg/kg). The mice in RTP1 group were poured through gastic route by RTP1 for 14 d, the mice in NC and IC group were given by 0.9% sodium chloride solution through the same way. The mice in all groups except NC group were irradiated with 6. 5 Gy 60 Co γ-ray on the fourteenth day. The 30 d sur- vival rate of mice was observed. The number of white blood cell (WBC) and bone marrow cell (BMC), as well as the count of endo-genous splenic colony-forming-unit (CFU-S) were detected. DNA content of marrow was also measured. RESULTS: Compared with that of the IC group, 30 d survival rate, the number of WBC and BMC, the count of CFU-S and the DNA content of marrow were significantly higher with a dose- dependent manner. CONCLUSION: RTP1 could improve the hematopoietic recovery after irradiation.关键词
唐古特大黄多糖/辐射损伤/66Coγ射线/造血系统Key words
Polysaccharide of rheum tanguticum/ radiation damage/ 60 Coγ ray/ Hematopoietic system分类
医药卫生引用本文复制引用
刘琳娜,郭志伟,张琰,张甜,张文娟,戚志华,徐媛..唐古特大黄多糖组分1对电离辐射损伤小鼠造血系统的影响[J].中国临床药理学与治疗学,2012,17(10):1087-1090,4.基金项目
国家自然科学基金资助项目(81073135) （81073135）
