中国临床药理学与治疗学2012，Vol.17Issue(10)：1102-1107,6.
雷莫司琼降低幼鼠内脏痛觉敏感性
Ramosetron decrease visceral pain hypersensitivity in young rats
摘要
Abstract
AIM: To explore the effects of 5-HT3 receptor antagonist ramosetron on young rats of visceral hypersensitivity by the methods of behavior and electrophysiology research. METHODS: Colorectal irritation (CD stimulation in neonatal period was used to establish the model of visceral hypersensitivity in young rats. 32 neonatal rats were divided into four groups by 2×2 factorial design with each 8. Group A, B1 was imposed on CI at neonatal period and imposed on ramosetron intraperitoneal injection in 15-21 day; Group A1B2 was imposed on CI at neonatal period and not imposed on ramosetron intraperitoneal injection; Group A2B1 was not imposed on CI at neonatal period and imposed on ramosetron intraperitoneal injection; Group A2B2 was not imposed on CI at neonatal period and not imposed on ramosetron intraperitoneal injection. Then, conventionally breeding till the young period (6-week age), abdonminal withdrawal reflex (AWR) , pain thresholds and spike external oblique muscle of abdomen (EOMA) were used to evaluate visceral pain hypersensitivity. RESULTS: he pain thresholds in young rats were affected both by CI at neonatal period and using ramosetron in 15-21 days. In group A1B2 which imposed on CI at neonatal period, the pain thresholds decreased 11. 56 mm Hg. In group A1B1 which imposed on CI at neonatal period and imposed on ramosetron in 15-21 day, the pain thresholds increased 9.06 mm Hg, while the AWR scores and EOMA were decreased. Future more, there are interaction effects between the two factors. There were a significant main effect for AWR scores at different pressures and a significant main effect for EOMA at different pressures. CONCLUSION: 5-HT3 receptor antagonist ramosetron can decrease visceral hypersensitivity in young rats.关键词
内脏痛高敏感/5-羟色胺3受体拮抗剂/雷莫司琼/幼鼠Key words
Visceral pain hypersensitivity/5-HT3 receptor antagonist / Ramosetron/ Young rats分类
医药卫生引用本文复制引用
林希,杨帆,吴斌,张晓燕,林春..雷莫司琼降低幼鼠内脏痛觉敏感性[J].中国临床药理学与治疗学,2012,17(10):1102-1107,6.基金项目
福建医科大学苗圃科研基金项目(2010MP012) （2010MP012）
