中国临床药理学与治疗学2012，Vol.17Issue(10)：1143-1150,8.
固定剂量复合剂(FDC)治疗肺结核的疗效和安全性的Meta分析
Meta-analysis on efficacy and safety of fixed-dose combination (FDC) in treatment of pulmonary tuberculosis
摘要
Abstract
AIM: To evaluate the efficacy and safety of fixed-dose combination for the treatment of pulmonary tuberculosis. METHODS: The studies related to the efficacy and safety of FDC in the treatment of newly diagnosed smear-positive pulmonary tuberculosis, and randomized clinical controlled trials (RCTs) or clinical controlled trials (CCTs) published in the openly journals either in Chinese or English were searched by computer, then searched references of included studies additionally. RESULTS: 22 studies were included. In the aspect of efficacy, Risk Ratio and its 95% CI of 2-month sputum negative conversion rate were 1. 02 (1. 01,1. 03) in FDC regimen, 6-month sputum negative conversion rate were 1. 01 (1. 00,1. 02) in FDC regimen, P<0. 05; relapse rate were 1.72 (0.98, 3. 02) in FDC regimen, P>0. 05. As for the e- valuation of safety, the total drug adverse e-vent, adverse events of skin , gastrointestinal adverse events, liver and biliary and discontinuation of medication were all no significant differences between FDC regimen and free-drug component regimen (P>0. 05). However, adverse events of gastrointestinal and discontinuation, liver and biliary of medication were unsteadiness by sensitivity analysis. CONCLUSION: The efficacy of FDC regimen was better than free-drug component regimen. The result of safety evaluation was unsteadiness, required more credibility evidences.关键词
固定剂量复合剂/肺结核/Meta分析Key words
Fixed-dose combination/ Pulmonary tuberculosis/ Meta-analysis分类
医药卫生引用本文复制引用
马婧婧,周泽文,颜陶,伍翔,王润华,易静..固定剂量复合剂(FDC)治疗肺结核的疗效和安全性的Meta分析[J].中国临床药理学与治疗学,2012,17(10):1143-1150,8.基金项目
国家自然科学基金"基于人工神经网络的结核病疫情预测研究及软件实现"资助项目(30872160) （30872160）
重庆市科委自然科学基金计划资助项目(CSTC,2009BB5415) （CSTC,2009BB5415）
