中国临床药理学与治疗学2012，Vol.17Issue(11)：1229-1232,4.
蛋白酶体抑制剂MG-132对柯萨奇B3病毒性心肌炎小鼠的作用研究
Effect of MG-132 in mice with acute viral myocarditis
张新民 1李岳春 1陈鹏1
作者信息
- 1. 温州医学院附属第二医院心内科,温州325000,浙江
- 折叠
摘要
Abstract
AIM: To determine the effect of proteasome inhibitor MG-132 in mice with acute viral myocarditis induced by coxsackievirus B3 virus (CVB3) infection. METHODS: BALB/C mice were intraperitoneally inoculated with CVB3 to induce myocarditis. From 24 h after infection, MG-132 was administered at a dose of 0. 75 mg/kg for 7 d continuously by intraperito-neal injection. Normal controls were treated with same volume of PBS. Then, the myocardial histopathological changes, HW/BW ratio, expression of myocardial CVB3 mRNA and serum cTn I and BNP were determined. RESULTS: MG-132 significantly attenuated myocardial le-
sions and decreased HW/BW ratio. It also remarkably decreased serum cTn I and BNP, down-regulated CVB3 mRNA expression compared with myocarditis controls. CONCLUSION; MG-132 protects against CVB3 induced viralmyocarditis in mice. MG-132 exerts its beneficial effect by downregulating CVB3 mRNA expression probably.关键词
泛素蛋白酶体系统/MG-132/小鼠/心肌炎/病毒复制Key words
Ubiquitin-proteasome system/MG-132/ Mice/ Viralmyocarditis/ Virus replication分类
医药卫生引用本文复制引用
张新民,李岳春,陈鹏..蛋白酶体抑制剂MG-132对柯萨奇B3病毒性心肌炎小鼠的作用研究[J].中国临床药理学与治疗学,2012,17(11):1229-1232,4.
