摘要
Abstract
AIM: To investigate the effects of irbesartan combined with glutathione sodium on oxidative stress in patients with diabetic nephropathy (DN) and to explore its function in the protection of kidney. METHODS: A total of 120 cases of DN were retrospectively analyzed in this study. The patients were divided into three groups: normal treatment group (A, n = 34), irbesartan treatment group(B, n = 42) , irbesartan combined with glutathione sodium treatment group(C, n = 44). The 24 h urine protein quan-titation, FGB, TG, BUN, SCr, K+ were determined before and after treatment. The activity of SOD was detected by spectrophotometer. The expression of MDA was detected by chromatom-etry. RESULTS:The 24 h urine protein quantita-tion, FGB, BUN, and SCr became better after different treatment ( P< 0. 05 ). However, the TG and K+ were not changed after different treatment(PX). 05). The changes of 24 h urine protein quantitation, FGB, BUN, and SCr were better in group B than those in group A(P<
0. 05). The changes of 24 h urine protein quantitation, FGB, BUN, and SCr were better in group C than those in group B(P<0. 05). After treatment, the SOD activity was elevated and the expression of MDA was decreased in group C. However , no change was found in group A and B(P> 0.05). The total effective rate in group A, B, and C was 44.1%, 61.9%, and 81.8%, respectively. The total effective rate in group C was higher than that in group A and B (P<0. 05). CONCLUSION: Irbesartan combined with glutathione sodium treatment significantly increases the activity of SOD and decreases the levels of MDA in patient with DN, which down-regulates oxidative stress, decreases urine protein quantitation, and shows protective function of of kendey.关键词
糖尿病肾病/厄贝沙坦/古拉定/氧化应激Key words
Diabetic nephropathy ( DN )/Irbesartan/ Glutathione sodium/Oxidative stress分类
医药卫生
