中国临床药理学与治疗学2012，Vol.17Issue(11)：1279-1282,4.
等效剂量阿芬太尼与芬太尼在全麻诱导时诱发咳嗽的对比研究
Comparison of cough induced by equivalent doses of alfentanil and fentanyl
帅训军 1艾登斌 1曹玺1
作者信息
- 1. 青岛市市立医院麻醉科,青岛266011,山东
- 折叠
摘要
Abstract
AIM: To evaluate the effects of cough induced by equivalent doses of alfentanil and fentanyl. METHODS: Fifty patients under-
going general anesthesia were randomly assigned to alfentanil group , and fentanyl group. Two groups were received equivalent doses of alfen-
tanil 8 μg/kg, and fentanil 2 μg/kg, via Ⅳ push within 5 seconds respectively. To observe the starting time incidence and severity of cough, heart rate ( HR) and mean arterial pressure (MAP) were recorded immediately before injection (T1) and 2 min (T2) after injection. RESULTS: Alfentanil group had an earlier starting time than fentanyl group, alfentanil group had a significantly lower incidence of cough than fentanyl group(P<0. 05). Compared with T1 , the HR and MAP of alfentanil group and fentanyl
group at T2 were significant lower(P<0. 05). Compared with fentanyl group, the extent of decrease in the HR and MAP of alfentanil group were significant higher ( P < 0. 05 ). CONCLUSION: Alfentanil induces a lower incidence of cough and more steadier circulation than equivalent doses of fentanyl.关键词
咳嗽/阿芬太尼/芬太尼Key words
Cough/ Alfentanil/ Fentanyl分类
医药卫生引用本文复制引用
帅训军,艾登斌,曹玺..等效剂量阿芬太尼与芬太尼在全麻诱导时诱发咳嗽的对比研究[J].中国临床药理学与治疗学,2012,17(11):1279-1282,4.
