中国临床药理学与治疗学2012，Vol.17Issue(11)：1289-1294,6.
尿酸转运蛋白研究进展
Progress in uric acid transporters
摘要
Abstract
Transport of uric acid by the kidneys rely on the transport protein in the renal tubular epithelial cells. Four kinds of urate transporters are involved in proximal tubular u-rate transport; human urate-anion exchanger 1 (hURAT1) , which is responsible for the reab-sorption of urate, human urate transporter (UAT) and organic anion transporter (OAT1 and OAT3), there are responsible for uric acid secretion. Recently, also found that the one re- sponsible for uric acid secretion into the extracellular, involved in the renal proximal tubule reabsorption of urate transporter protein - glucose transporter protein (GLUT9). This article summarized the features, functions and regulatory mechanisms of uric acid transport protein.关键词
高尿酸血症/尿酸转运蛋白/进展Key words
Hyperuricemia/ Uric acid transporters/ Progress分类
医药卫生引用本文复制引用
朱立然,陈光亮..尿酸转运蛋白研究进展[J].中国临床药理学与治疗学,2012,17(11):1289-1294,6.基金项目
国家自然科学基金资助项目(81073112) （81073112）
