中国临床药理学与治疗学2012，Vol.17Issue(11)：1314-1320,7.
二甲双胍对骨代谢的影响
Effects of metformin on bone metabolism
摘要
Abstract
Metformin [ l-( diaminomethyli-dene)-3 , 3-dimethylguani-dine] is an antihyper-glycemia drug commonly used for the management of type 2 diabetes, which has been widely used for more than fifty years and had safety, valid and full-scale effects on controlling plasma glucose in patients with diabetes mellitus. Recent years, more and more studies found that metformin induced osteoblastic growth and differentiation, increased the mineralization of the extracellular matrix, reversed the deleterious effects of high glucose on osteoblast function and also inhibited osteoclastogenesis; Furthermore, in vivo, treatment of mice with metformin has been found to increase bone mineral content, trabecular bone volume and induce bone forma- tion. In addition, using a model of minimal bone defect metformin treatment stimulated bone reossification in both control and diabetic rats. Furthermore, in clinical research, metformin influenced bone mineral density in patients with diabetes mellitus. However, the effects of metformin on bone metabolism and the molecular mechanisms for the action of metformin are still unclear. This article reviews the effects of metformin on bone metabolism and discusses its possible mechanisms.关键词
二甲双胍/成骨细胞/破骨细胞Key words
Metformin/ Osteoblast/ Osteo-clast分类
医药卫生引用本文复制引用
甄东户,刘丽娟,汤旭磊,成建国..二甲双胍对骨代谢的影响[J].中国临床药理学与治疗学,2012,17(11):1314-1320,7.基金项目
兰州大学中央高校基本科研业务费专项资金资助自由探索项目(lzujbky-2010-199) （lzujbky-2010-199）
