中国临床药理学杂志2012，Vol.28Issue(11)：843-845,3.
康脑液对脑缺血再灌注大鼠GFAP和NeuN表达的影响
Effect of Kangnaoye on the expression of GFAP and NeuN in rats with cerebral ischemia
摘要
Abstract
Objective To observe the effect of Kangnaoye on the ex-pression of glial fibrillary acidic protein ( GFAP) and neuronal nuclear an-tigen (NeuN) in rats with cerebral ischemia and reperfusion. Methods These rats were randomly divided into 5 groups; sham - operated group, model group, high - dose kangnaoye group, middle - dose Kang-naoye group and low - dose kangnaoye group. The model of focal cerebral ischemia and reperfusion was induced in rats with the intraluminal suture method. The expression of GFAP and NeuN were determined by immuno-histochemistry method at different time after cerebral ischemia. Results The groups treated with Kangnaoye had a lower expression of GFAP than the model group ( P < 0. 05 or P < 0. 01) at day 3 , day 7 , day 14 and day 21 after cerebral ischemia. Until the day21 after cerebral ische-mia and reperfusion, the expression of GFAP of Kangnaoye group approx-imated the level of normal. Compared with model group, the expression of the NeuN of groups treated with Kangnaoye were significantly higher than the model group (P < 0. 05 or P < 0. 01). Conclusion Kangnaoye can inhibit the over expression of GFAP, promote neural stem cell differ-entiation into neurons, and advance nerve regeneration and repair.关键词
康脑液/缺血再灌注/胶质纤维酸性蛋白/神经元核抗原Key words
Kangnaoye/cerebral ischemia and reperfusion/glial fibril-lary acidic protein/neuronal nuclear antigen分类
医药卫生引用本文复制引用
耿倩,邹玉安,薛茜..康脑液对脑缺血再灌注大鼠GFAP和NeuN表达的影响[J].中国临床药理学杂志,2012,28(11):843-845,3.基金项目
河北省卫生厅课题基金资助项目(20090591) （20090591）
