中国临床医学影像杂志2012，Vol.23Issue(12)：837-840,844,5.
18F-FDG与18F-FLT PET/CT在肺结核瘤与恶性肿瘤鉴别诊断中的应用
Differential diagnosis of pulmonary tuberculomas and malignant nodules using 18F-FLT and 18F-FDG PET/CT imaging
陈文新 1赵周社 2郭莘 1陈国宝 1林美福 1田嘉禾 3杨小丰 4于丽娟 5王雪梅 6辛军 7冯慧如 8陈萍9
作者信息
- 1. 福建医科大学省立临床医学院核医学科,福建福州 350001
- 2. 美国通用电气医疗系统集团,北京 100176
- 3. 中国人民解放军总医院,北京 100853
- 4. 新疆维吾尔自治区人民医院,新疆乌鲁木齐830001
- 5. 哈尔滨医科大学第三附属医院,黑龙江哈尔滨150001
- 6. 内蒙古医学院附属医院,内蒙古呼和浩特 010000
- 7. 中国医科大学附属盛京医院,辽宁沈阳 110004
- 8. 北京军区总医院,北京 100700
- 9. 广州医学院第一附属医院,广东广州510120
- 折叠
摘要
Abstract
Objective: To investigate the diagnostic efficacies of 18F-FLT and 18F-FDG PET/CT in pulmonary nodules, focusing on diagnosis and differential diagnosis of pulmonary tuberculomas and malignant nodules. Materials and Methods: 163 patients with solitary pulmonary nodules undergoing dual-tracer imaging were certified by histological findings. The patients were collected from a multicenter clinical trial and were divided into the group of pulmonary tuberculoma(n=29), group of other benign nodule(n=48) and group of malignant nodule(n=88). The images were read in a standardized, blind, collective reading. The standardized uptake value (SUV) of l8F-FDG and 18F-FLT were compared and analyzed. Results: The SUVs of FDG and FLT in groups of malignant nodule, tuberculoma and other benign nodule were in a decreasing order. Both SUVFDG and SUVFLT showed significant difference in the group of malignant nodule and tuberculoma (P<0.001). ROC curve showed that a SUV cutoff of 5.9 on FDG PET/CT and 2.4 on FLT PET/CT provided the best separation of tuberculomas and malignancies. FLT PET/CT had higher diagnostic efficacy than FDG PET/CT(P<0.001). The ratio between SUVs of I8F-FLT and 18F-FDG improved the diagnostic efficacy in comparison with single tracer imaging. Conclusions: Dual-tracer imaging using 18F-FDG/18F-FLT PET/CT provides a better diagnostic efficacy in these clinically challenging patients with pulmonary lesions. A SUV cutoff of 5-9 on FDG PET/CT and 2.4 on FLT PET/CT provide the best separation of tuberculomas and malignancies. The ratio between SUVs of l8F-FLT and I8F-FDG provides great potential benefits in separating tuberculomas and malignancies.关键词
结核,肺/肺肿瘤/氟脱氧葡萄糖F18/正电子发射断层显像术Key words
Tuberculosis, pulmonary/ Lung neoplasms/ Fluorodeoxyglucose F18/ Positron-emission tomography分类
医药卫生引用本文复制引用
陈文新,赵周社,郭莘,陈国宝,林美福,田嘉禾,杨小丰,于丽娟,王雪梅,辛军,冯慧如,陈萍..18F-FDG与18F-FLT PET/CT在肺结核瘤与恶性肿瘤鉴别诊断中的应用[J].中国临床医学影像杂志,2012,23(12):837-840,844,5.
