中国免疫学杂志2012，Vol.28Issue(11)：999-1001,1005,4.DOI:10.3969/j.issn.1000-484X.2012.11.008
香菇多糖和黄芪多糖对免疫抑制小鼠免疫功能调节的研究
Effect of Lentinan and Astragalus Polysaccharides on immunological function in immunosuppressed mice
摘要
Abstract
Objective: To investigate the effect of Lentinan and Astragalus polysaccharides on immunoregulation in mice . Methods: After oral administration of the two polysaccharides , immune effect of the two polysaccharides on the whole immunity was in -vestigated through delayed type hypersensitivity (DTH) , visceral organs index , NK cell activity (lactate dehydrogenase releasing method) , lymphocyte proliferation capacity (MTT) and the level of IL-2, IL-4, IL-40, IFN-γ( ELISAs) of immunosuppressed mice induced by cyclophosphamide. Results: Cyclophosphamide -treated mice showed a significant decrease in DTH , NK cell activity and the serum level of cytokines (each was P <0. 05) ; Both Lentinan and Astragalus polysaccharides accelerated recovery of DTH (P < 0.05 ) , as well as NK cell activity ( P < 0. 01) and restored the level of IL -2, IL-4, IL40, IFN-γ in the serum. Conclusion: Both Lentinan and Astragalus polysaccharides can significantly stimulate the immune function in mice with immunologic suppression ; the im— munological enhancement effect of Lentinan is obviously better than Astragalus polysaccharides .关键词
免疫调节/黄芪多糖(APS)/香菇多糖(LNT)/Th1/Th2免疫平衡Key words
Immunoregulation/ Astragutus polysaccharide (APS) / Lentinan (LNT) / Thl/Th2 immune balance分类
医药卫生引用本文复制引用
颜爱,李波,李润成,喻凯,余兴龙..香菇多糖和黄芪多糖对免疫抑制小鼠免疫功能调节的研究[J].中国免疫学杂志,2012,28(11):999-1001,1005,4.基金项目
本文为长沙科技计划重大专项(K0902007-21) （K0902007-21）
