中国全科医学2012，Vol.15Issue(35)：4140-4142,3.DOI:10.3969/j.issn.1007-9572.2012.12.069
早期气管内滴入以氨溴索为载体的布地奈德防治早产儿呼吸窘迫综合征的效果研究
Effect of Early Intratracheal Instillation of Budesonide Using Mucosolvan as A Vehicle to Prevent and Cure Neonatal Respiratory Distress Syndrome
摘要
Abstract
Objective To analyze the effects of early intratracheal instillation with budesonide using mucosolvan as a vehicle on neonatal respiratory distress syndrome ( NRDS ) in the preterm infants. Methods The study adopted prospective controlled clinical trial. 87 preterm infants ( gestational ages ≤ 32 weeks or birth weights < 1 500 g ) admitted to our hospital from January 2010 to May 2012 were randomly divided into control group ( 41 cases, intratracheal instillation of a mixture of pul-momary surfactant and budesonide at early stage after birth ) and observation group ( 46 cases, intratracheal instillation of a mixture of high - dose mucosolvan and budesonide at early stage after birth ). The infants of both groups were given nasal continuous positive pressure ( nCPAP). The prevalence, cure rate, invasive mechanical ventilation rate and the survival rate at 36 weeks' post - conceptional age ( PCA ) of the two groups were analyzed. Results Before treatment, in the control group, 32 cases had NRDS and 9 cases had no NRDS; In observation group, 28 cases had NRDS and 18 cases had no NRDS. The prevalence of NRDS between the two groups showed no statistically significant difference ( χ2 = 2. 9892, P = 0. 0838 ). After treatment, no new case was found in the two groups. The cure rate in the control group and observation group was 97% ( 31/32 ) and 96% ( 27/28 ) respectively, and the difference was not statistically significant ( χ2 =0. 0002, P =0. 9900 ). The invasive mechanical ventilation rate in the control group and observation group was 31% ( 10/32 ) and 32% ( 9/28 ) respectively, and the difference was not statistically significant (χ2 =0. 0029, P =0. 9574 ). The two groups were followed up at 36 weeks' post - conceptional age, 1 case in the control group and 2 cases in the observation were lost to following up. 2 cases ( 5% ) in the control group and 3 cases ( 7% ) in the observation group were died, and the difference was not statistically significant (χ2 = 0. 1099, P = 0. 7402 ). Conclusion Early intratracheal instillation of high - dose mucosolvan and budesonide together with nCPAP could prevent and cure NRDS as effectively as intratracheal instillation of pulmomary surfactant and budesonide, increasing the survival rate of preterm infants. Therefore, it could be promoted in clinic as an effective, cheap and easy - extended method.关键词
透明膜病/布地奈德/氨溴索Key words
Hyaline membrane disease/ Budesonide/ Ambroxol分类
医药卫生引用本文复制引用
刘东成,劳庆禄,陆妹,李卫东,何源,李源斌,迟春昕,伍全概..早期气管内滴入以氨溴索为载体的布地奈德防治早产儿呼吸窘迫综合征的效果研究[J].中国全科医学,2012,15(35):4140-4142,3.基金项目
中山市科技计划项目(20102A106) （20102A106）
