中国全科医学2012，Vol.15Issue(36)：4166-4168,3.DOI:10.3969/j.issn.1007-9572.2012.12.079
慢性肾衰竭患者血清Chemerin水平及其与肾功能的关系研究
Serum Chemerin Level in Patients with Chronic Renal Failure and Its Relationship to Renal Functon
施良 1毛朝明 1李龙 1高健青 1周建明1
作者信息
- 1. 212001,江苏省镇江市,江苏大学附属医院核医学科
- 折叠
摘要
Abstract
Objective To investigate serum levels of adipokine chemerin in patients with chronic renal failure ( CRF ) and its relationship to renal function. Methods One hundred and fifty -eight 3-4 stage CRF outpatients and patients admitted to hospital from June 2010 to March 2012 were enrolled as CRF group, and 140 healthy subjects receiving physical examinations at corresponding period as control group. Enzymes linked immunosorbent assay ( ELISA ) was used to determine serum chemerin and high sensitive C - reactive protein ( hs - CRP ), radionuclide dynamic imaging to measure glomerular filtration rate ( GFR ), and biochemical method to detect blood urea nitrogen ( BUN ), serum creatinine ( Scr ). The relationship of the above indexes to serum chemerin was observed. Results Serum Chemerin and hs - CRP levels were higher in CRF group than in control group [ (101. 3 ±31. 7) μg/Lvs. (68. 4 ±25. 4) μg/L, t=2. 656, P <0. 01 and ( 3. 80 ±0. 88 ) g/L vs. (1.60 ±0.76) g/L, t = 2. 241, P < 0. 05 ]. Serum Chemerin was negatively correlated with GFR ( r = -0. 58, P < 0. 01 ), and positively with BUN, Scr and hs - CRP ( r =0.43, P <0. 05; r=0. 51, P <0. 05; r=0. 41, P <0. 01). The multiple stepwise regression analysis showed that GFR was independent variables of serum Chemerin. Conclusion Chemerin level is related to renal function in CRF patients.关键词
Chemerin/肾功能衰竭,慢性/肾小球滤过率Key words
Chemerin/ Kidney failure, chronic/ Glomerular filtration rate分类
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施良,毛朝明,李龙,高健青,周建明..慢性肾衰竭患者血清Chemerin水平及其与肾功能的关系研究[J].中国全科医学,2012,15(36):4166-4168,3.
