中国输血杂志Issue(10)：1002-1004,3.
HBV感染者红细胞膜CD35分子表达和循环免疫复合物的变化及意义
The changes and significance of erythrocyte CD35 and circulating immune complex in HBV infected individuals
彭明喜 1张哲 2汤晓娴 2许德义 1王峰3
作者信息
- 2. 宁波市中心血站,浙江宁波315040
- 3. 李惠利医院
- 折叠
摘要
Abstract
Objective To observe the expression of human erythrocyte membrane CD35 and the changes of Circulating Immune complex(CIC)in serum content of HBV infection, study of erythrocyte in HBV infection effects. Methods The expression of human erythrocyte membrane CD35 was evaluated through flow cytometric analysis in 102 HBV infections and 30 healthy controls. Ciq - ELISA was used to detect the serum level of CIC Results Compare with the controls the acute hepatitis,chronic hepatitis,severe hepatitis erythrocyte membrane CD35+- E(%)and CD35-GMFIR in HBV infections were all significantly lower( all P <0. 05) ,and the serum level of CIC were markedly higher than the controls ( all P < 0. 01) ,but the asymptomatic infections have no significant difference with the controls in erythrocyte membrane CD35 +- E ( % ) and CD35 -GMFIR and the serum level of CIC ( all p > 0.05); All of the subjects. CD35 + - E (% ) was positively correlated with CD35-GMFIR( r = 0. 896, P < 0. 01); CD35 + - E (% ) and. CD35-GMFIR were all negatively correlated with CIC (r = - 0. 862 、r = - 0.795, P < 0.05). Conclusion In HBV infections, ervthrocyte CD35 molecule expression level and the serum level of CIC can sensitively reflect the severity of hepatitis,contribute to the diagnosis of patients with hepatitis, erythrocyte membrane CD35 contributes to the HBV clearance.关键词
HBV/感染/CD35/循环免疫复合物Key words
HBV infection/ CD35/ Circulating Immune complex分类
医药卫生引用本文复制引用
彭明喜,张哲,汤晓娴,许德义,王峰..HBV感染者红细胞膜CD35分子表达和循环免疫复合物的变化及意义[J].中国输血杂志,2012,(10):1002-1004,3.
