中国实验动物学报2012，Vol.20Issue(6)：26-30,后插4,6.DOI:10.3969/j.issn.1005-4847.2012.06.006
尿微量白蛋白、尿β2-微球蛋白、转铁蛋白、糖化血红蛋白联合检测在糖尿病动物模型中的应用
Application value of combined detection of urine microalbumin, β2-microglobulin, transferrin, glycated hemoglobin and serum lipids in macaque monkey models of diabetes mellitus
摘要
Abstract
Objective To explore the application value of combined detection of microalbumin , β2-microglobulin, TRF, glycated hemoglobin and serum lipids in diabetic rhesus macaque models . Methods Streptozotocin in a dose of 30 mg/kg of body weight was intravenously injected to five rhesus macaque for consecutive 3 days. The dynamic changes of u — rine microalbumin, β2-microglobulin, TRF, glycated hemoglobin were measured for 13 months. Results |β2-microglobu-lin and transferrin were significantly higher than those before STZ injection ( P <0. 05) . The metabolism of TC and HDL-C were abnormal 6 months after STZ injection. Abnormal TG and LDL-C metabolism occurred 9 months after STZ injection. Significantly positive correlations were observed between TRF and β2-MG (F =0. 242, 0. 153, P < 0. 05) , mALB and TRF (F=0. 213, P< 0. 05), as well as HbAlc and β241GTRF ( F =0. 153, 0.097, P< 0.05). There was a positive correlation between urine mALB and p241G (F =0. 242, 0. 153, P < 0. 05), between TRF and β2-G (F =0.213, P < 0. 05), and between HbAlc and β2-MG (F =0.153, 0.097, P < 0. 05). Single factor linear regression analysis showed that TRF was a correlation factor of mALB and β2 -MG ( P < 0. 05 ). Conclusions The results show that the combined de -tection of urine microalbumin , β2 -inicroglobulin, glycated hemoglobin and serum lipids can be used in rhesus macaque mod -els of diabetes mellitus , and are useful in their early monitoring, diagnosis, therapy and prognosis.关键词
尿微量白蛋白/尿β2-微球蛋白/糖化血红蛋白/恒河猴Key words
Urine albumin/Urine β2-nicroglobulin/Urine glycated hemoglobin/Serum lipid/rhesus macaque分类
生物科学引用本文复制引用
朱华,刘颖,黄澜,徐艳峰,马春梅,赵春华,秦川..尿微量白蛋白、尿β2-微球蛋白、转铁蛋白、糖化血红蛋白联合检测在糖尿病动物模型中的应用[J].中国实验动物学报,2012,20(6):26-30,后插4,6.基金项目
863课题(2009ZX09503-025). （2009ZX09503-025）
