中国实验动物学报2012，Vol.20Issue(6)：82-84,后插8,4.DOI:10.3969/j.issn.1005-4847.2012.06.018
海洛因成瘾模型建立及中脑腹侧被盖区Bax的表达
Effect of heroin on Bax expression in the brain ventral tegmental area and establishment of a rat model of heroin addiction
摘要
Abstract
Objective To study the effects of heroin on Bax expression in the midbrain ventral tegmental area (VTA) of rat. Methods Heroin was intramuscularly injected into rats and a rat model of addiction was generated . Bax expression in the midbrain ventral tegmental area (VTA) was detected by i m muno hist o chemistry. Results The rats had significant withdrawal symptoms after continuous injection of heroin for 7 days. The expression of Bax-positive cells in cere-bellar cortex of rat was significantly increased than that in the control group ( P < 0. 01 ). Conclusion Heroin has effect of inducing Bax gene expression and damage to brain cells .关键词
海洛因/Bax/中脑腹侧被盖区/大鼠Key words
Heroin/Bax/Midbrain ventral tegmental area (VTA)/Addiction/Rat分类
生物科学引用本文复制引用
俞发荣,连秀珍,谢明仁,张红梅,李立新,张琛,李世平..海洛因成瘾模型建立及中脑腹侧被盖区Bax的表达[J].中国实验动物学报,2012,20(6):82-84,后插8,4.基金项目
甘肃省自然科学基金(编号:甘财教[2010]148号) （编号:甘财教[2010]148号）
甘肃省高校学科带头人扶持项目计划基金(编号:甘教字[2011]23号) （编号:甘教字[2011]23号）
甘肃省证据科学技术研究与应用重点实验室科技计划项目基金(编号:ZDSYS-Y17). （编号:ZDSYS-Y17）
