中国实用儿科杂志2012，Vol.27Issue(11)：863-865,3.
单次小剂量静脉输注免疫球蛋白提升血小板作用观察
Study of efficacy of single low-dose intravenous immunoglobulin in elevating platelet counts
赵卫红 1华瑛 1卢新天 1马岳红 1孙青1
作者信息
- 1. 北京大学第一医院儿科,北京 100034
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of single low-dose intravenous immunoglobulin (IVIG) in treatment for children with newly diagnosed immune thrombocytopenia (ITP). Methods Of 62 children with newly diagnosed ITP, 30 patients admitted to hospital before October 2009 were initially given standard-dose prednisone(steroids group) ,and 32 from October 2009 to April 2011 initially received IVIG [400 mg/(kg -d) ] treatment for 1 ~ 5 days (IVIG group). Platelet counts were evaluated after presentation days 1,3,5 and in the follow-up. Results The mean platelet counts in steroids group and IVIG group were 10 x 109/L and 6 x 109/L before treatment.By day 1 after treatment,43.57%children in IVIG group had rapid platelet count recovery, reaching safe level (30 x l09/L) , which was higher than 3.33% in steroids group(P < 0.01 ).By day 3 and 5, the percentage of cases with platelet count increasing above 30 x 109/L in steroids group arid IVIG group were 46.67% vs 65.63% and 80.00% vs 81.25% , respectively.After 7-42 months of follow-up, there were 3.45% in steroids group and 3.23%in IVIG group whose platelet count didn't turn normal.No intracranial hemorrhage or death was recorded. Conclusion Childhood ITP patients treated with one low-dose IVIG (400 mg/kg) demonstrate a higher percentage with platelet count increasing above 30 x l09/L on the second day; compared with those treated with prednisone initially, the effect is much better.关键词
免疫性血小板减少性紫癜,儿童/免疫球蛋白,小剂量/醋酸泼尼松Key words
immune thrombocytopenia, children/intravenous immunoglobulin, low-dose/prednisone分类
医药卫生引用本文复制引用
赵卫红,华瑛,卢新天,马岳红,孙青..单次小剂量静脉输注免疫球蛋白提升血小板作用观察[J].中国实用儿科杂志,2012,27(11):863-865,3.
