中国实用妇科与产科杂志2012，Vol.28Issue(12)：924-927,4.
早孕期甲状腺过氧化物酶抗体阳性对甲状腺功能的影响
An analysis of maternal thyroid peroxidase autoantibody positivity in the first trimester
摘要
Abstract
Objective To assess the prevalence of thyroid peroxidase autoantibody and relationships between thyroid function and TPOAb in the first trimester of pregnancy. Methods A total of 611 women during the first trimester from Beijing Friendship Hospital are tested for serum TSH, FT4 and anti-TPO by chemilumino metric immunoanalysis . Women with previous thyroid diseases are excluded. We determine the reference intervals for TSH and FT4 and establish the prevalence of TPOAb by using gestational age -specific interval. The relationships between TSH,FT4 and TPOAb are analyzed. Results (1)The median value of TPOAb is 38. 9 mU/L,ranging from 6. 4 to more thanl 300 mU/L at 8-12 gestational week . (2) The cutoff value of TPOAb is 206. 77 mU/L at the 90th percentile by using gestational age-specific interval. The positive rate of TPOAb is 10. 8% (66/611). (3) A simple regression analysis shows that serum titer of TPOAb correlates with the levels of TSH and FT4 (P = 0. 000 and 0. 000) . The median concentration of TSH is significantly greater in TPOAb-positive women than in TPOAb-negative women with increased value of 0. 40 mU/L. The risk of abnormally high TSH in former is more than three times than in latter. Conclusion TPOAb positive rate is 10. 8% in first trimester. Determination of the gestational age-specific intervals for TSH, FT4 and TPOAb is of very importance to avoid o-verestimation of maternal thyroid dysfunction. Pregnant women with TPOAb-positive have a higher level of TSH and should be monitored closely for thyroid function.关键词
早孕期/甲状腺过氧化物酶抗体/孕周特异甲状腺功能参考区间Key words
first trimester/ thyroid peroxidase autoantibody/ gestational age-specific intervals for thyroid function分类
医药卫生引用本文复制引用
龙燕,时娟娟,张晓璐,蔺莉..早孕期甲状腺过氧化物酶抗体阳性对甲状腺功能的影响[J].中国实用妇科与产科杂志,2012,28(12):924-927,4.基金项目
北京市科委科研课题(D101100050010033) （D101100050010033）
