摘要
Abstract
Objective To study the diagnostic value of combined determination of serum CA125 ,LASA,TPA,CATL and 0VX1 in patients with early stage EOC. Methods EOC group 86、the benign epithelial ovarian tumor group 100 and healthy women group 50 of Lanzhou University Second Hospital and First Hospital of Lanzhou between 2007 and 2010; Serum levels of LASA, TPA, CATL and OVX1 were ascertained by enzyme-linked immunosorbent assay ( ELISA ) .The clinical data of the corresponding period patients with ovarian tumor were collected to analyze the serum level of CA125. Results The serum levels of CA125 ,LASA,TPA,CATL and 0VX1 in EOC group were significantly higher than the benign epithelial ovarian tumor group and healthy women group(P <0. 05 ,respectively) . In single test,the total positive rate and early diagnosis rate of TPA for EOC are highest;the total positive rate of LASA and OVX1 are inferior to CA125,the total positive rate of CATL are slightly above CA125, but the early diagnosis rate of others are higher than CA125. In the joint test, the total positive rate and early diagnosis rate of TPA plus CA125 for EOC are highest,the early diagnosis rate of others joint with CA125 are higher than CA125 single (P <0. 05 , respectively) ,the total positive rate for EOC are higher than CA125 single( P < 0. 05, respectively), except CA125 plus OVX1 . Conclusion The serum levels of CA125,LASA,TPA,CATL and OVX1 all could be used as the important tumor markers of EOC,CA125 and TPA together is the best,can improve the total positive rate ,early diagnosis rate and the diagnosis rate of EOC.关键词
糖类抗原125/卵巢上皮性癌/脂类唾液酸/组织多肽抗原/组织蛋白酶L:卵巢癌抗原X1Key words
CA125/EOC/LASA/TPA/CATL /OVX1分类
医药卫生
