中国实用内科杂志2012，Vol.32Issue(12)：946-948,3.
2型糖尿病合并非酒精性脂肪肝患者血浆同型半胱氨酸与胰岛素抵抗相关性研究
Correlation between serum homocysteine and insulin resistance in patients as having type 2 diabetes mellitus with concomitant non-alcoholic fatty liver disease
摘要
Abstract
Objective To investigate the correlation between serum homocysteine (HCY) and insulin resistance in patients as having type 2 diabetes meilitus (T2DM) with concomitant non-alcoholic fatly liver disease (NAFLD). Methods We recruited 156 patients with T2DM who were admitted to department of endocrinology and metabolism,The Qingpu Branch of Zhongshan Hospital, Fudan University,between March 2010 and March 2012. Eligible patients were subsequently allocated to groups ( DM + N ) and DM, respectively, based on the presence of NAFLD as diagnosed via history inquiry and ultra-sonography. A total of 65 subjects who underwent clinical health check-up were allocated in group NC. Fasting plasma glucose (FPG) ,fasting insulin (FINS) and HCY concentrations were assayed,and the insulin resistance index ( HOMA-IR) was calculated. Results Higher levels of FPG,FINS,glycosylated hemoglobin (HbA1c) .total glycerin (TG) ,total cholesterol (TC) ,low-density lipoprotein-cholesterol (LDL-C) ,body mass index (BMI) ,alanine transferrase (ALT) , HOMA-IR and HCY were evidenced in groups ( DM + N) and DM ( all P < 0. 05 ) , but not in group NC. Group ( DM + N) was associated with higher 1 evels of ALT,TG,FPG,FINS,HOMA-IR and HCY (all P <0.05) as compared with group DM. Both HOMA-IR and TG were shown as the independent influencing factors of HCY. Conclusion Patients as having T2DM with concomitant NAFLD may be featured by increased plasma HCY that has been shown to correlate with IR.关键词
2型糖尿病/非酒精性脂肪肝病/胰岛素抵抗/同型半胱氨酸Key words
type 2 diabetes meilitus/non-alcoholic fatty liver disease/insulin resistance/homocysteine分类
医药卫生引用本文复制引用
张敏,张剑,叶晓梅..2型糖尿病合并非酒精性脂肪肝患者血浆同型半胱氨酸与胰岛素抵抗相关性研究[J].中国实用内科杂志,2012,32(12):946-948,3.基金项目
国家自然科学基金资助项目(30800360) （30800360）
留学回国人员科研基金(教育部国际合作与交流司,第40批留学回国人员科研启动基金) （教育部国际合作与交流司,第40批留学回国人员科研启动基金）
