中国实用外科杂志2012，Vol.32Issue(10)：809-811,3.
肝癌术后复发发生机制及临床病理学意义
Mechanism of recurrent hepatocellular carcinoma and clinicopathological significance
摘要
Abstract
Based on molecular pathology, recurrent HCC (RHCC) can be divided into two types: one is monocentric (monoclonal) origin presenting postoperative residual recurrence, and the other is multicentric (multiclonal) origin, meaning a second primary tumor, which can be further divided into six subtypes with concomitant clonal types. However, according to the field cancerization hypothesis, there also exists the possibility of the so called second field tumor , which leads to a more complex mechanism and patterns of RHCC. Because correct determination of the clonal origin of RHCC may have actual reference value for personalized therapy, more attention should be paid to establish molecular clonal techniques suitable for pathological lab and to explore the clinical pathway in the diagnosis and treatment of RHCC based on their clonal classifications.关键词
复发性肝癌/克隆起源/分子病理学Key words
recurrent hepatocellular carcinoma/ clonal origin/ molecular pathology分类
医药卫生引用本文复制引用
丛文铭,吴孟超..肝癌术后复发发生机制及临床病理学意义[J].中国实用外科杂志,2012,32(10):809-811,3.基金项目
国家自然科学基金资助项目(30872506,81072026) （30872506,81072026）
上海市科委重点科技项目(10411951000) （10411951000）
