中国体外循环杂志2012，Vol.10Issue(4)：203-206,4.
乌司他丁对法洛四联症根治术婴幼儿的心肺保护作用
Cardiopulmonary protective effects of ulinastatin in infants with tetralogy of Fallot underwent radical surgery
摘要
Abstract
Objective To investigate eareliopulmonary protective effeets of ulinastatin in infants with te;tralogy of Fallot ( TOF ) underwent radical surgery unele;r eandiopulmonary bypass. Methods From June 2011 through Mareh 2012, 40 sueeessive infante with TOF seheduled for raelical surgery were randomly gronpeel as ulinastatin group ( UTI group, 20 cases ) and control group ( CTL group, 20 eases ). UTI patie;nts reeeiveel 10 000 U/kg of ulinastatin in prime; solution for eanliopiilmonaiy bypass, and the same close of ulinastatin per day for 3 days after snrgery. CTL infants reeeiveel equal volume ef saline at the same time points. The peri- operative; parame-ters, sueh as cperating time, eardiopulmonaiy bypass time, eareliae arrest time, ICU time, post- operative length of stay, mean arterial pressure; ( MAP ) anel eentral venous pressure ( CVP ) immeeliately after moelifieel ultrafiltratietn, post - operative inotropic seores, PaO2 , PaCO2 anel peak prcssure of airway ( Ppcak ) upon ICU arrival, ventilation time anel post - operative pulmonary infcetions were rccorded. Results There was no hospital eleath in either group. There was no statistical diffcrenee between the two groups as to operating time, eareliopidmonaiy bypass time, careliae arrest time, ICU time and the ratio of spetntane;ous rhythm rccovery after aortic eross-clamp remotvai. Compareel with CTL group, patients in UTI group had higher MAP, letwer CVP right separation from moelifieel ultrafil-tration, anel shorte;r post - operative; length etf stay. The post - operative; inotropic seore;s in UTI group were signifieantly roelueed com-pare;el with CTL patients ( P <0. 05 ). There was no statistieai eliffercnee befween the two groups in the values of PaCO2. UTI patients had higher value of PaO2 , lower Ppeak in the same ventilation condition upon ICU admission. There were significantly less pulmonary infections in UTI patients ( 2/20 ) compared with CTL patients ( 8/20 ). Conclusion Peri - operative application of ulinastatin in infants with TOF underwent radical surgery under cardiopulmonary bypass is safe and has potential cardiopulmonary protective effects.关键词
乌司他丁/法洛四联症/婴幼儿Key words
Ulinastatin/ Tetralogy of Fallot/ Infants分类
医药卫生引用本文复制引用
王显悦,毕生辉,王晓武,张卫达,梅鲁刚,梁爱琼,徐宇,金振晓..乌司他丁对法洛四联症根治术婴幼儿的心肺保护作用[J].中国体外循环杂志,2012,10(4):203-206,4.基金项目
广州市科技计划项目(2011J4100021) （2011J4100021）
天普研究基金(01201122,01201104) （01201122,01201104）
