中国心理卫生杂志2012，Vol.26Issue(12)：933-937,5.DOI:10.3969/j.issn.1000-6729.2012.12.011
哌甲酯治疗后注意缺陷多动障碍核心症状与执行功能改善的关系
Improvements of attention deficit/hyperactivity disorder core symptoms and executive function after methylphenidate treatment
摘要
Abstract
Objective: To investigate the correlation between the improvements of attention deficit/hyperactivity disorder (ADHD) core symptoms and executive function after methylphenidate treatment Methods: Eighty-five ADHD children meeting the Diagnostic and Statistical Manual of Mental Disorders,'Fourth Edition (DSM-IV) diagnostic criteria were treated open-labeled with the Osmotic release oral system ( OROS) methylphenidate. The Core symptoms and executive functions were evaluated at the baseline and the end of the study respectively, with the ADHD Rating Scale (ADHD-RS-IV) for core symptoms, as well as the performance-based tests (Stroop color-word interference task, Rey complex figure test, Digit span, Tower of Hanoi, Trail-making test, Verbal fluency test) and Behavior Rating Inventory (BRIEF) for Executive Function. Pearson correlation was used to analyze the relationship between improvements of core symptoms and executive functions. Results: Only the improvement of delayed structural score in Rey Complex Figure Test for visual working memory was mild correlated to the decrease of ADHD-RS-IV rating scores (r =0. 19 ~0. 24, Ps <0. 05). The decrease on BRIEF total score, metacognition Index (MI), Behavior Regulation Index, BRI, and each factor were mild to moderate correlated to the decrease of ADHD-RS-IV rating scores (r = 0. 19-0. 66, Ps < 0. 05), in which, the correlation between the decrease of inattention sub-scale and those of teacher rated BRIEF total score, MI and its four factors (excluding initiation), BRI and its inhibition factor was moderate (r = 0. 51 ~0. 69, Ps <0. 05), and the correlation between the decrease of hyperactive-impulsive subscale and those of teacher rated BRIEF BRI and its inhibition factor was moderate (r = 0. 54 ~ 0. 64, Ps <0. 05). Conclusion: It suggests that the ADHD core symptoms improvement after methylphenidate treatment may be correlated with executive function improvement, especially for inattention symptoms moderately correlated to MI improvement, and hyperactive-impulsive symptoms moderately correlated to inhibition improvement.关键词
注意缺陷多动障碍/执行功能/哌甲酯/症状/相关Key words
attention deficit/hyperactivity disorder/ executive function/ methylphenidate/ symptom/ correlation分类
医药卫生引用本文复制引用
杨莉,苏怡,曹庆久,钱英,李海梅,帅澜,王玉凤..哌甲酯治疗后注意缺陷多动障碍核心症状与执行功能改善的关系[J].中国心理卫生杂志,2012,26(12):933-937,5.基金项目
卫生部公益性行业专项(儿童注意缺陷多动障碍的病因、发病机理及诊疗研究,200802073),西安杨森临床研究课题(CON-I-07-CN-029-B) （儿童注意缺陷多动障碍的病因、发病机理及诊疗研究,200802073）
