中国畜牧兽医2012，Vol.39Issue(11)：22-26,5.
纳米铜对大鼠肝脏毒性的蛋白质组2-DE图谱分析
2-DE Map Analysis of Proteomics in Rat with the Hepatotoxic Mechanisms of Nanoparticles Copper
摘要
Abstract
In order to obtain protein expression map of nanoparticles copper(nano-copper) toxicity in rat liver, this study constructed the model of the nano-copper in rats, and obtained 2-DE maps of nano-copper toxicity in rats group and control group used by two-dimensional gel electrophoresis technique, PDQuest 8. 0 analysis showed that the total 43 protein spots significantly differently expressed in rat liver of 200 mg/kg copper nanoparticles group which 27 spots were up and 16 spots were down. The toxicity of nano-copper in rats liver was studied by proteomics approach in the paper, the results would establish the foundation for clarifying the mechanism of the toxic effects of nano-copper at protein level.关键词
蛋白质组学/2-DE/纳米铜/大鼠Key words
proteomics/2-DE/nanoparticles copper/ral分类
生物科学引用本文复制引用
高昭辉,董书伟,薛慧文,申小云,荔霞..纳米铜对大鼠肝脏毒性的蛋白质组2-DE图谱分析[J].中国畜牧兽医,2012,39(11):22-26,5.基金项目
国家现代农业产业技术体系建设专项资金项目(CARS-40-30). （CARS-40-30）
