中国循证儿科杂志2012，Vol.7Issue(6)：450-453,4.DOI:10.3969/j.issn.1673-5501.2012.06.010
基于733例择期手术患儿的EB病毒感染血清流行病学调查
Serological epidemiology investigation of Epstein-Barr virus infection based on 733 children to be operated
刘亚丽 1闫静 1关晓蕾 1艾军红 1谢正德1
作者信息
- 1. 首都医科大学附属北京儿童医院北京市儿科研究所,教育部儿科重大疾病研究重点实验室,北京,100045
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摘要
Abstract
Objective To investigate the serological epidemiology of Epstein-Barr vims( EBV ) infection in children in Beijing. Methods Seven hundred and thirty three children without symptoms and signs of infection from the surgical department of Beijing Children's Hospital were enrolled into this study. Three antibodies against EBV including CA-IgG, NA-IgG and CA-IgM were examined by using enzyme linked immunosorbent assay( ELISA ). Results 733 children were included ( 414 males, 319 females ). Children in ＜ 1, - 5 , - 10 and - 17 years groups were 306, 193 , 147 and 87 cases respectively. The total seropositive rate was 70.4％ of CA-IgG, 68.4％ of NA-IgG and 0. 7％ of CA-IgM respectively. The positive rates of CA-IgG and of NA-IgG were 54. 2％ and 51. 3％ in ＜ 1 year group respectively, and increased with the age. The highest positive rates of CA-IgG and NA-IgG both were 90. 8％ in - 17 years group. The CA-IgM was only detected in five sera samples. The cumulative infection rate of EBV in ＜ 1, - 5 , - 10 and - 17 years groups were 54. 2％ , 74. 6％ , 86. 4％ , 90. 8％ and recent infection rates were 2.1％, 2.0％ , 0％ , 11. 1％. The cumulative infection rate significantly differed between males and females in - 17 years group. Conclusions The primary infection of EBV in children occurs at their childhood. The seropositive rate of EBV is about 90％ at the age of 10 years in children. Compared with the age of EBV seroconversion in 1980s, the age has delayed with the improvement of social economic status.关键词
EB病毒/血清流行病学/EB病毒抗体/儿童Key words
Epstein-Barr virus/ Serological epidemiology/ EBV antibody/ Children引用本文复制引用
刘亚丽,闫静,关晓蕾,艾军红,谢正德..基于733例择期手术患儿的EB病毒感染血清流行病学调查[J].中国循证儿科杂志,2012,7(6):450-453,4.
