摘要
Abstract
OBJECTIVE: To study cough relieving and sputum removing effect of 5 different solvent extracts of Pinellia ternata on mice. METHODS: The sputum removing effect was evaluated with phenol red excretion. 70 kunming mice were divided into blank control group (constant volume of normal saline), ammonium chloride(0.5 g·kg-1) group, alcohol extract off! Ternate(\2 g·kg-1) group, water extract of P. Temate(1.2 g·kg-1) group, petroleum ether extract of P. Ternate(1.2 g·kg-1) group, ethyl acetate extract of P. Ternate(1.2 g·kg-1) group, butanol extract of P. Ternate (1.2 g·kg-1) group. All groups were given medicine intra
gastrically once a day for consecutive 7 days except for ammonia chloride group. Ammonia chloride group was given medicine once on 7th day.The cough relieving effect was evaluated with ammonia water induced cough model. 70 kunming mice were divided into model control group (constant volume of normal saline), codeine(0.002 g·kg-1) group, alcohol extract of P. Ternate(0.6 g·kg-1) group, water extract of P. Ternate(0.6 g·kg-1) group, petroleum ether extract of P. Ternatei 0.6 g·kg-1) group, ethyl acetate extract of P. Ternate(0.6 g·kg-1) group, butanol extract of P. Ternate(0.6 g·kg-1) group. All groups were given medicine intragastrically once a day for consecutive 7 days except for codeine group. Ammonia chloride group was given medicine once on 7th day. The incubation period of cough and cough frequency in 2 min. RESULTS: Compared with the model control group, phenol red excretion of each treatment group increased significantly(P<0.01 or P<0.05), especially butanol extract of P. Ternate; Compared with the model control group, the incubation period of cough in each treatment group were obviously prolonged, while cough frequency was significantly reduced in 2 min(P<0.01 or P<0.05), especially butanol extract of P. Ternate. CONCLUSION: Among 5 different solvent extracts of f! Ternata, butanol extract show the best cough relieving and sputum removing effect, which can provide reference for the clinic.关键词
半夏/正丁醇/酚红排泄量/氨水引咳Key words
Pinellia ternate/ Butanol/ Phenol red excretion/ Ammonia water induced cough分类
医药卫生
