中国药房2012，Vol.23Issue(39)：3686-3689,4.DOI:10.6039/j.issn.1001-0408.2012.39.14
蛇床子素β-环糊精包合物的制备及稳定性考察
Preparation and Stability Study of Osthol-β-CD Inclusion Complex
王周丽 1贝永燕 1顾宗林 1朱爱军 1陈维良 1施林森 1张学农1
作者信息
- 1. 苏州大学药学院药学系,江苏苏州215123
- 折叠
摘要
Abstract
OBJECTIVE: To prepare the inclusion complex of osthol-β-cyclodextrin (osthol-β-CD), and to investigate the stability of inclusion complex. METHODS: The inclusion complex of osthol-/?-CD was prepared by counter mixture stirring method. The content, solubility and dissolution of osthol in inclusion complex were determined by UV spectrophotometry. Using the content of osthol as the inspection index, the inclusion complex of osthol-β-CD was examined with intense light, high temperature and humidity test. RESULTS: The formation of the inclusion complex was confirmed by microscope examination, UV absorption spectrum scanning, thermal analysis, etc. The solubility of inclusion complex increased about 34 times. The accumulative dissolving quantity of inclusion complex was about 2.5 times the drug substance within 120 min. The content of osthol showed no significant changes in the inclusion compounds but noticeable changes in the physical mixture of osthol and β-cyclodextrin. CONCLUSION: The results indicate that the inclusion complex can improve the solubility and dissolution of osthol. Osthol-β-CD has the characteristics of anti-light, anti-heat and anti-humidity, and the stability of it is better than that of osthol mixture.关键词
蛇床子素/β-环糊精包合物/紫外分光光度法/溶解度/溶出度/稳定性Key words
Osthol/ β-cyclodextrin inclusion complex/ UV spectrophotometry/ Solubility/ Dissolution/ Stability分类
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王周丽,贝永燕,顾宗林,朱爱军,陈维良,施林森,张学农..蛇床子素β-环糊精包合物的制备及稳定性考察[J].中国药房,2012,23(39):3686-3689,4.
