中国药房2012，Vol.23Issue(40)：3798-3800,3.DOI:10.6039/j.issn.1001-0408.2012.40.21
比索洛尔对原发性高血压患者左心室重构及血浆脑钠肽的影响
Effects of Bisoprolol on Essential Hypertension on Left Ventricular Remodeling and Plasma Brain Natriuretic Peptide Levels
摘要
Abstract
OBJECTIVE: To observe the effects of bisoprolol on left ventricular remodeling (LVR) and plasma brain natriuretic peptide (BNP) levels in essential hypertension patients. METHODS: Based on routine treatment, 47 patients with primary hypertension were given Bisoprolol fumarate tablets for 24 consecutive weeks. The changes of blood pressure were observed before and after treatment. The color Doppler ultrasonic diagnostic apparatus was adopted for determination of thickness of interventricular septum (IVST) , left ventricular posterior wall thickness (LVPWT) , left ventricular end diastolic diameter (LVEDd) , left ventricular end-diastolic diameter (LVEDs) and left ventricular ejection fraction (EF), left ventricular mass index (LVMI) and left ventricular wall thickness (RWT) before and after treatment; microparticle enzyme analysis method was used for the determination of BNP levels in plasma, with 30 healthy cases as control in the same period. RESULTS: RWT, LVMI and plasma BNP levels in patients with EH complicating with left ventricular hypertrophy (LVH) were significantly higher than in normal control group (P<0.01), while EF was significantly lower than in normal control group (P<0.01) ; the plasma level of BNP were positively correlated to LVEDd, LVEDs, LVMI (P<0.01), and negative correlated to EF (P<0.01). After treatment of bisoprolol, blood pressure of EH patients decreased significantly (P<0.01), and total clinical efficiency was 80.9%; ventricular remodeling index improved significantly (P<0.05 or P<0.01), and plasma levels of BNP were significantly reduced (P<0.01). No severe ADR was found. CONCLUSION: Bisoprolol shows sound antihypertensive efficacy and tolerability, reverse left ventricular remodeling and improve heart function in patients with EH. It has certain effect on plasma BNP secretion in EH patient.关键词
原发性高血压/左心室重构/脑钠肽/比索洛尔Key words
Essential hypertension/ Left ventricular remodeling/ Brain natriuretic peptide/ Bisoprolol分类
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王俊,陈安,孙国香..比索洛尔对原发性高血压患者左心室重构及血浆脑钠肽的影响[J].中国药房,2012,23(40):3798-3800,3.
