中国药房2012，Vol.23Issue(41)：3872-3874,3.DOI:10.6039/j.issn.1001-0408.2012.41.12
维库溴铵对家兔定量药物脑电图的影响
Effects of Vecuronium on Quantitative Pharmaco-electroencephalography in Rabbits
摘要
Abstract
OBJECTIVE: To investigate the effects of vecuronium on quantitative pharmaco-electroencephalography (QPEEG) in conscious and anesthesia rabbits and establish its model. METHODS: Rabbits were divided into conscious group and anaesthesia group with 8 rabbits in each group. They were all given vecuronium 0.3 mg·kg-1 intravenously, and anaesthesia group was additionally anaesthetized by pentobarbital intravenously before medication. Based on QPEEG, EEG changes of rabbits in 8 brain regions and 6 bands power (δ,θ,α1,α2,β1,β2) were checked in conscious group before medication and 5～35 min after medication and in anaesthesia group before medication and 0.5～10 min after medication by power spectral analysis. RESULTS: For conscious rabbits, compared with before administration, the percentage of the 8 band power in 8 brain regions increased notably 5～35 min after administration (P<0.01); the percentage of θ (except for left and right forehead, P<0.01 or P<0.05), α1, α2 band power had no significant change in any brain regions (P>0.05); while that of β1, β2 band power lowered remarkably (P<0.01). Compared with different time points after administration, the percentages of 6 bands power had no obvious variation in 8 brain regio- ns at each time point (P>0.05). For anesthesia group, the percentage of each band power had no significant change in various brain regions at each time point before and after administration (P＞0.05). CONCLUSION: Vecuronium can increase the percentage of 5 band power and lower β1, β2 band power in conscious rabbits. Vecuronium have no significant effect on QPEEG in anesthesia rabbits.关键词
定量药物脑电图/功率谱分析法/维库溴铵/兔/清醒/麻醉Key words
Quantitative pharmaco-electroencephalography/ Power spectral analysis/ Vecuronium/ Rabbits/ Conscious/ Anesthesia分类
医药卫生引用本文复制引用
韩平平,蔡慧明,吴克俭,王琦,戴体俊..维库溴铵对家兔定量药物脑电图的影响[J].中国药房,2012,23(41):3872-3874,3.基金项目
国家自然科学基金资助项目(30872432、30471657、39970715) （30872432、30471657、39970715）
