中国药房2012，Vol.23Issue(41)：3910-3911,2.DOI:10.6039/j.issn.1001-0408.2012.41.28
HPLC法测定苹果酸舒尼替尼胶囊中主药的含量
Content Determination of Main Component in Sunitinib Malate Capsules by HPLC
冯亚宁 1周会芹2
作者信息
- 1. 南京华东医药有限责任公司,南京210016
- 2. 盐城市药品检验所,江苏盐城224002
- 折叠
摘要
Abstract
OBJECTIVE: To establish a method for the content determination of main component in Sunitinib malate capsules. METHODS: HPLC method was adopted. Shimadzu C16 column was used with mobile phase consisted of ammonium acetate buffer (pH 6.8)-acetonitrile (55:45) at the flow rate of 1.0 mL·min-1. The detection wavelength was set at 430 nm and column temperature was 35 ℃. RESULTS: The linear range of sunitinib malate was 5～25 μg·mL-1 (r-=0.999 7) with an average recovery of 99.65% (RSD=0.66%, n=9). CONCLUSION: The method is simple, accurate and precise, and it is applicable for the determination of Sunitinib malate capsules.关键词
苹果酸舒尼替尼胶囊/高效液相色谱法/含量测定Key words
Sunitinib malate capsules/ HPLC/ Content determination分类
医药卫生引用本文复制引用
冯亚宁,周会芹..HPLC法测定苹果酸舒尼替尼胶囊中主药的含量[J].中国药房,2012,23(41):3910-3911,2.
