中国药房2012，Vol.23Issue(42)：3966-3967,2.DOI:10.6039/j.issn.1001-0408.2012.42.12
肾移植患者他克莫司血药浓度监测的临床分析
Clinical Analysis of Blood Concentration Monitoring of Tacrolimus in Renal Transplantation Recipients
邹素兰 1蒋艳 1陈荣1
作者信息
- 1. 常州市第一人民医院临床药学室,江苏常州213003
- 折叠
摘要
Abstract
OBJECTIVE: To study the blood concentration monitoring of tacrolimus (Tac) in renal transplantation recipients, and to provide reference for use of Tac in the clinic. METHODS: 110 renal transplantation recipients were selected, and relationship of post-operative time, dosage, gender, age with blood concentration of Tac was analyzed statistically. RESULTS: The dose and blood concentration of Tac decreased gradually with time 1 month after transplantation, with great individual difference. The gender had small effect on blood concentration of Tac at the same period (P>0.05). The blood concentration and dose of Tac in group C (>60 years old) were lower than in group A (13～45 years old) and group B (45～60 years old) after operation (P< 0.05); the blood concentration and dose of Tac had no significant difference between group A and group B (P>0.05). CONCLUSION : It is necessary to monitor the blood concentration of Tac to avoid excessive and insufficient immunity, toxic responses and improve the kidney survival rate.关键词
肾移植患者/他克莫司/血药浓度Key words
Renal transplantation/ Tacrolimus/ Blood concentration分类
医药卫生引用本文复制引用
邹素兰,蒋艳,陈荣..肾移植患者他克莫司血药浓度监测的临床分析[J].中国药房,2012,23(42):3966-3967,2.
