中国药房2012，Vol.23Issue(43)：4068-4070,3.DOI:10.6039/j.issn.1001-0408.2012.43.14
紫外分光光度法测定姜黄素白蛋白纳米混悬剂的包封率
Determination of Encapsulation Efficiency of Curcumin Albumin Nanosuspensions by UV Spectrophotometry
张华 1张卿 1贾运涛 2张良珂 1田睿 3滕永真3
作者信息
- 1. 重庆医科大学药学院,重庆400016
- 2. 重庆医科大学附属儿童医院药剂科,重庆400014
- 3. 重庆医科大学生命科学院,重庆400016
- 折叠
摘要
Abstract
OBJECTIVE: To establish the method for the determination of encapsulation efficiency of Curcumin albumin nanosuspensions. METHODS: Centrifuging was applied to isolate free drug and the content of curcumin was determined at 422 nm by UV spectrophotometry. The encapsulation efficiency of Curcumin albumin nanosuspensions was calculated. RESULTS: Curcumin showed a good linear relationship within a range of 0.5~6.0 mg-L~'(r=:0.999 9) with an average recovery of 98.50% (RSD= 2.74% ,n=9).The encapsulation efficiency was 42.32%. CONCLUSION: The method is easy to operate, highly accurate, reliable in results and can be used for the determination of encapsulation efficiency of Curcumin albumin nanosuspensions.关键词
紫外分光光度法/姜黄素/白蛋白/纳米粒混悬剂/包封率Key words
UV spectrophotometry/ Curcumin/ Albumin/ Nanosuspensions/ Encapsulation efficiency分类
医药卫生引用本文复制引用
张华,张卿,贾运涛,张良珂,田睿,滕永真..紫外分光光度法测定姜黄素白蛋白纳米混悬剂的包封率[J].中国药房,2012,23(43):4068-4070,3.
