中国药房2012，Vol.23Issue(44)：4161-4164,4.DOI:10.6039/j.issn.1001-0408.2012.44.12
CYP4F2、CYP2C9和VKORC1基因多态性对中国汉族非瓣膜性房颤患者使用华法林剂量的影响
Effects of CYP4F2,CYP2C9 and VKORC1 Genetic Polymorphisms on Maintenance Dosage of Warfarin in Chinese Han Nationality Patients with Non-valve Atrial Fibrillation
摘要
Abstract
OBJECTIVE: To investigate the effect of gene polymorphism, including the CYP4F2, and clinical factors on the dose of warfarin in Chinese Han nationality with non-valve atrial fibrillation (NVAF). METHODS: CYP2C9*3, VKORC1 1173 and CYP4F2 were genotyped by using the ligase detection reaction (LDR) method. Multiple linear regression analysis was used to investigate the effects of gene polymorphism of CYP4F2 and clinical factors on the individual dose of warfarin. RESULTS: The CYP4F2 TT group took a significantly higher dose of warfarin (3.04 ± 0.98) mg than wild-type group [(2.60 ± 0.84) mg, P= 0.034]. Gene polymorphisms of CYP2C9*3, VKORC1 1173 and CYP4F2, age, body weight, previous thromboembolism, amioda-rone and p-blockers explained 51.7% of the variance in dose of warfarin. CYP4F2 contributed about 4.8% to the variance in the dose of warfarin. CONCLUSION: Gene polymorphism of CYP4F2 is a significant factor of individual variability in the dose of warfarin in Chinese Han patients with NVAF. The individual dosing regimens might improve the safety of warfarin therapy for NVAF patients based on clinical factors and gene polymorphism.关键词
华法林/非瓣膜性房颤/细胞色素P450酶4F2/基因多态性/中国人/汉族Key words
Warfarin/ Non-valve atrial fibrillation/ CYP4F2/ Gene polymorphism/ Chinese/ Han nationality分类
医药卫生引用本文复制引用
朱君荣,魏萌,朱余兵,谢渡江,于锋,叶飞,陶宜富..CYP4F2、CYP2C9和VKORC1基因多态性对中国汉族非瓣膜性房颤患者使用华法林剂量的影响[J].中国药房,2012,23(44):4161-4164,4.基金项目
南京药学会-常州四药医院药学科研基金暨南京市科技发展计划(药学项目)(2011YX002) （药学项目）
