中国药房2012，Vol.23Issue(48)：4543-4546,4.DOI:10.6039/j.issn.1001-0408.2012.48.10
尼莫地平治疗蛛网膜下腔出血的系统评价
Nimodipine in the Treatment of Subarachnoid Hemorrhage:a Systematic Review
摘要
Abstract
OBJECTIVE: To evaluate efficacy and safety of nimodipine in the treatment of subarachnoid hemorrhage (SAH). METHODS: System review, Meta-analysis and random controlled trails (RCT) of nimodipine vs. placebo for SAH were retrieved from Cochrane library,Pubmed,EMbase,ISI,CBM,CNKI, VIP, Wangfang database and Chinese biomedical literature service system. Quality evaluation of included studies was conducted and Meta-analysis was performed using Rev Man5.0 software. RESULTS: 8 RCTs were included, involving 2 223 patients. Meta-analysis showed that the mortality has no statistical significance in 2 groups [RR=0.67,95%CI(0.44, 1.03), P=0.07]. The prevention of cerebral ischemia of both groups had statistical significance [RR= 0.57, 95% CI(0.42, 0.78)], P=0.000 4]. There was no statistical significance in the difference of ADR in 2 groups. CONCLUSION: Nimodipine can effectively prevent the occurrence of cerebral ischemia in patients with subarachnoid hemorrhage. However, nimodipine has no advantage in prevention of mortality.关键词
尼莫地平/蛛网膜下腔出血/有效性/安全性/Meta分析Key words
Nimodipine/Subarachnoid hemorrhage/Efficacy/Safety/Meta-analysis分类
医药卫生引用本文复制引用
白向荣,李晓玲,王育琴..尼莫地平治疗蛛网膜下腔出血的系统评价[J].中国药房,2012,23(48):4543-4546,4.基金项目
科技部国家科技支撑计划分课题(2009BAI76B030203) （2009BAI76B030203）
