中国医科大学学报2012，Vol.41Issue(12)：1123-1126,4.
肾盂癌中EpCAM和E-Cadherin的表达及临床意义
Expression and Clinicopathologic Significance of EpCAM and E-Cadherin in Urothelial Carcinoma of Renal Pelvis
摘要
Abstract
Objective To investigate the pmgnostic value of EpCAM and E-Cadherin in urothelial carcinoma of rpnal pelvis. Methods Ep-CAM and E-Cadherin were analyzed by immunohistochemistry using monoclonal antiliodies in 50 cases of normal mucosa and 76 cases of urothelial carcinoma of renal pelvis. Results The positive rate of EpCAM in urothelial carcinoma of renal pelvis was 60.5% .which was significantly higher than in para-cancerous mucosa of 27.6%. The expression of EpCAM was significantly related with the differential clinical stage,pathological degree,distant metastasis and bladder tumor recurrence (all P< 0.05). The expression of E-Cadherin was significantly re-lated with the differential clinical stage,pathological degree and distant metastasis (all P < 0.05). There was negative correlation between the expression of EpCAM and E-Cadherin in urothelial carcinoma of renal pelvis ( r =-0.425,P < 0.01). Conclusion The expression EpCAM and E-Cadherin are highly related to occurrence,development,infiltration and metastasis of urothelial carcinoma of renal pelvis,and evaluation of the two proteins could be a very applicable guidance for the diagnosis of metastasis and invasion of urothelial carcinoma of renal pelvis.关键词
肾盂癌/上皮特异性黏附分子/E-钙黏素/免疫组织化学方法Key words
urothelial carcinoma of renal pelvis/EpCAM/E-Carlherin/inimunohisloehemical method分类
医药卫生引用本文复制引用
单立平,卜仁戈,张墨,李波,吴斌,宋永胜..肾盂癌中EpCAM和E-Cadherin的表达及临床意义[J].中国医科大学学报,2012,41(12):1123-1126,4.基金项目
国家自然科学基金资助项目(30901480),沈阳市科学技术计划项目(f11-262-9-12) （30901480）
