中国药理学通报2012，Vol.28Issue(12)：1629-1633,5.DOI:10.3969/j.issn.1001-1978.2012.12.001
蛋白磷酸酶1与Ca2+ /钙调素依赖性蛋白激酶Ⅱ在心肌病中研究进展
Roles of protein phosphatase 1 and Ca2+/calmodulin-dependent protein kinase Ⅱ in heart disease
摘要
Abstract
Phosphorylation and dephosphorylation of protein play an important role in the process of signal transduction, and its cycle, similar to the switching which regulates molecular, involves in many physiological activities. Protein kinases and protein phosphatases are a critical regulated pathway of phosphorylation and dephosphorylation of protein. Protein phosphatase l( PP1 ) is a multifunctional protein phosphatase and plays an important role in pathogenesis of cardiac hypertrophy and heart failure. Ca2 + /calmodulin-dependent protein kinase Ⅱ ( CaMK Ⅱ ) is also a multifunctional enzyme involved in the regulation of gene expression, cell cycle control, and differentiation. There is growing evidence for a pathophysiological role of CaMK Ⅱ in cardiac hypertrophy and heart failure. The article focuses on the progress in roles of PP1 and CaMK Ⅱ in cardiac physiology and pathophysiology.关键词
蛋白磷酸酶1/Ca2+/钙调素依赖性蛋白激酶Ⅱ/心肌疾病/心脏病/磷酸化/去磷酸化/第二信使Key words
protein phosphatase 1/ Ca2+ /calmodulin-dependent protein kinase Ⅱ / cardiomyopathies/ heart diseases/ phosphorylation/ dephosphorylation/ second messenger分类
医药卫生引用本文复制引用
廖儒佳,曹雯雯,张伟..蛋白磷酸酶1与Ca2+ /钙调素依赖性蛋白激酶Ⅱ在心肌病中研究进展[J].中国药理学通报,2012,28(12):1629-1633,5.基金项目
国家自然科学基金资助项目(No 81070197) （No 81070197）
江苏省高校研究生创新计划(No YKC11032,YKC12019) （No YKC11032,YKC12019）
