中国药理学通报2012，Vol.28Issue(12)：1633-1636,4.DOI:10.3969/j.issn.1001-1978.2012.12.002
线粒体与心肌缺血/再灌注损伤
Mitochondria and myocardial ischaemia/reperfusion injury
摘要
Abstract
Myocardial ischaemia/reperfusion ( I/R ) cause a wide array of alterations of mitochondrial homeostasis, such as loss of ATP synthesis, increase of ROS generation, Ca2+ overload, membrane permeabilization, fragmentation of mitochondria and so on. The series of events are linked together and involved in the process of I/R injury, play critical roles in cardiomyocytes injury. This paper reviews the advancement of mitochondrial pathological changes during I/R and mitochondrial protective pathway of I/R injury, in order to understand the important mechanisms of I/R injury associated with mitochondria and provide references for cardiovascular disease treatment strategies and drug development based on mitochondrial protection.关键词
缺血/再灌注/线粒体膜通透性/线粒体形态/ROS/Ca2+/mPTP/mKATPKey words
ischaemia/reperfusion/ mitochondrial permeability/mitochondrial morphology/ ROS/ Ca + / mPTP/ mKATP分类
医药卫生引用本文复制引用
李雪丽,刘建勋..线粒体与心肌缺血/再灌注损伤[J].中国药理学通报,2012,28(12):1633-1636,4.基金项目
国家自然科学基金重点项目(No 30830118) （No 30830118）
重大新药创制综合性中药新药研究开发技术平台(No 2009ZX09301-005-007) （No 2009ZX09301-005-007）
