中国药理学通报2012，Vol.28Issue(12)：1690-1694,5.DOI:10.3969/j.issn.1001-1978.2012.12.014
亚胺培南或美罗培南联合利福平降低不动杆菌防耐药突变浓度的体外研究
Study on decreasing mutant prevention concentrations of imipenem or meropenem in combination with rifampicin against Acinetobacter in vitro
摘要
Abstract
Aim To investigate the mutant prevention concentrations of imipenem or meropenem alone and in combination with rifampicin against Acinetobacter in vitro, which provided evidence for new strategies for restricting the development of resistance. Methods The minimal inhibitory concentrations of imipenem, meropenem, rifampicin, imipenem or meropenem in combination with rifampicin against 16 Acinetobacter strains were tested by agar dilution method , and the fractional inhibitory concentration indexes were calculated. The cells of 1010 colony forming units per millili-ter Acinetobacter were enriched in broth. The mutant prevention concentrations of the above drugs against 16 Acinetobacter strains were detected with agar dilution method, and the selectivity indexes were calculated. Results The primary action of imipenem or meropenem in combination with rifampicin in vitro showed no interaction. The minor action was synergy. And there was no antagonistic effect observed. The selectivity indexes of imipenem and meropenem alone against 16 Acinetobacter strains were 16 ~ 128, and those of the combination application with rifampicin for Acinetobacter were both 1 ~32. The selectivity indexes for the combination application both decreased by 2 ~ 32-fold. Conclusion Combination application of antimicrobial agents can decrease mutant prevention concentrations of Acinetobacter, and narrow the mutant selection windows , so the emergence of resistant strains can be decreased.关键词
不动杆菌/防耐药突变浓度/耐药突变选择窗/亚胺培南/美罗培南/联合用药Key words
Acinetobacter/ mutant prevention concentrations/ mutant selection window/ imipenem/ meropenem / combination application of drugs分类
医药卫生引用本文复制引用
马慧敏,胡立芬,叶英,朱玉林,李家斌..亚胺培南或美罗培南联合利福平降低不动杆菌防耐药突变浓度的体外研究[J].中国药理学通报,2012,28(12):1690-1694,5.基金项目
国家自然科学基金资助项目(No 81172737,81071394) （No 81172737,81071394）
