中国药理学通报2012，Vol.28Issue(12)：1741-1746,6.DOI:10.3969/j.issn.1001-1978.2012.12.025
重组人角质细胞生长因子-2对实验秃毛大鼠的毛发再生作用
Effects of recombinant human keratinocyte growth factor-2 on hair regeneration in experimental bald rats
摘要
Abstract
Aim To establish the experimental bald rat model and study the effect of recombinant human keratinocyte growth factor -2( rhKGF2 )on hair regeneration in experimental bald rat. Methods The hair of SD rats was removed by paste, and these SD rats were then randomly divided into seven groups, including normal group,5% minoxidil group,aFGF group,rhKGF2 high-dose group, rhKGF2 middle-dose group, rhKGF2 low-dose group,0. 9% saline group. Skin was treated with different medications as described above the day after hair removal. Body weight, hair length, hair weight, and the hair growth conditions were recorded on days 1,5,9 and 14 after treatment. The rats were sacrificed on day 14, and the experimental skin was used for his-topathological examination. Results Body weight of rats: compared with normal group, there was no significant difference in each group ( P > 0. 05 ) on days 1, 5,9, and 14; Hair length of rats: compared to 0. 9% saline group, there were significant differences in rh-KGF2 high-dose ( P <0. 05 ) and rhKGF2 middle-dose groups ( P < 0. 01 ) on days 5 and 9. On day 14, compared with 0. 9% saline group, there were significant differences in rhKGF2 high ( P < 0. 05 ), middle( P < 0. 01 ) and low-dose( P < 0. 05 ) groups; Hair weight of rats: On day 14, compared with 0.9% saline group, there were significant differences among ather groups ( except for normal group ) ( P < 0. 01 ); Histological findings: RhKGF2 played an important role in the formation and maturation of hair follicles in the experimental bald rats. Conclusion RhKGF2 plays an important role in hair regeneration in the experimental bald rats. RhKGF2 has good prospects for clinical application.关键词
重组人角质细胞生长因子-2/秃毛大鼠/毛发再生/作用/毛囊/临床应用Key words
factor -2/ bald rats/ hair regeneration/ effect/ follicle/ clinical application分类
医药卫生引用本文复制引用
王泽,黄鹏煌,赵海洋,李海燕,田海山,李校堃..重组人角质细胞生长因子-2对实验秃毛大鼠的毛发再生作用[J].中国药理学通报,2012,28(12):1741-1746,6.基金项目
国家科技重大专项"重大新药创制"(No 2008ZX09101-057) （No 2008ZX09101-057）
吉林省科技型中小企业创新基金项目(No SC201102022) （No SC201102022）
