中国医学科学院学报2012，Vol.34Issue(6)：585-589,5.DOI:10.3881/j.issn.1000-503X.2012.06.009
鳞癌相关性高钙血症的临床特点及预后因素
Clinical Characteristics and Prognostic Factors of Malignancy-associated Hypercalcemia in Squamous Cell Carcinoma
张素洁 1胡毅 1焦顺昌 1刘哲峰 1陶海涛1
作者信息
- 1. 中国人民解放军总医院肿瘤内科,北京100853
- 折叠
摘要
Abstract
Objective To explore the clinical characteristics and prognostic factors of patients diagnosed with squamous cell carcinoma (SCC) and presented malignancy-associated hypercalcemia ( MAH). Methods We retrospectively analyzed the clinical data of 36 patients with biopsy-proven SCC and presented MAH who were treated at the our department from January 2001 to December 2010. The survival were analyzed using the Kaplan-Meier method and Cox analysis. Results Among these 36 patients, the median blood calcium level was 2. 94 mmol/L (2. 77-4. 87 mmol/L) , and the median survival time was only 45 days (1 -839 d). Log-rank test showed that central nervous system symptoms, bone metastasis, and hypercalcemia occurring over 160 days after cancer diagnosis were predictors for poor survival (P = 0. 003 , P = 0. 049 , P = 0. 005 ). In the COX proportional hazard model analysis, central nervous system symptoms and hypercalcemia occurring over 160 days after cancer diagnosis were independent prognostic factors for survival time (RR = 5. 721, P = 0. 000; RR=A. 624, P = 0.001). Conclusions Patients with squamous cell carcinoma (SCC) and presented MAH have poor prognosis. Central nervous system symptoms and hypercalcemia occurring over 160 days after cancer diagnosis are independent predictors of the prognosis.关键词
高钙血症/鳞癌/预后因素Key words
hypercalcemia/ squamous cell carcinoma/ prognostic factor分类
医药卫生引用本文复制引用
张素洁,胡毅,焦顺昌,刘哲峰,陶海涛..鳞癌相关性高钙血症的临床特点及预后因素[J].中国医学科学院学报,2012,34(6):585-589,5.
