中国医学科学院学报2012，Vol.34Issue(6)：640-644,5.DOI:10.3881/j.issn.1000-503X.2012.06.021
芳羟基受体相互作用蛋白基因与家族性单纯性垂体腺瘤
Aryl Hydrocarbon Receptor Interacting Protein Gene and Familial Isolated Pituitary Adenomas
蔡锋 1张熠丹 1代从新 1刘小海 1杨亚坤 1姚勇 1王任直1
作者信息
- 1. 中国医学科学院北京协和医学院北京协和医院神经外科,北京100730
- 折叠
摘要
Abstract
Familial isolated pituitary adenoma ( FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.关键词
芳羟基受体相互作用蛋白基因/家族性单纯性垂体腺瘤Key words
aryl hydrocarbon receptor interacting protein gene/ familial pituitary adenoma分类
医药卫生引用本文复制引用
蔡锋,张熠丹,代从新,刘小海,杨亚坤,姚勇,王任直..芳羟基受体相互作用蛋白基因与家族性单纯性垂体腺瘤[J].中国医学科学院学报,2012,34(6):640-644,5.
