中国药业2012，Vol.21Issue(21)：13-14,2.
加巴喷丁片剂的溶出度研究
Study on Dissolubility of Gabapentin Tablets
摘要
Abstract
Objective To establish a method for determining the dissolution rate of Gabapentin Tablets. Methods The content of Cabapentin Tablets was determined by the ninhydrin photometric method with the detection wavelength of 570 nm. With 900 mL water as solvent, the rotating speed of 100 r/min and the temperature of (37 ±0.5)℃, the homogeneity of dissolution rate and the batch-to - batch reproducibility in 5 batches of Gabapentin Tablets were determined within 8, 10, 12, 15, 30 min by the rotating basket method. Results and Conclusion The dissolution homogeneity of five batches of samples is good and the dissolution rates all were above 90%. The ninhydrin photometric method can be used to determine the dissolution rate of this products关键词
抗癫痫药/加巴喷丁片剂/溶出度/比色法Key words
antiepileptic drug/ Gabapentin Tablet/ dissolution rate/ colorimetry分类
医药卫生引用本文复制引用
李彩文,陈宝泉,卢学磊,麻静,王瑞..加巴喷丁片剂的溶出度研究[J].中国药业,2012,21(21):13-14,2.基金项目
2010年天津理工大学教学基金项目,项目编号:YB10-29 （）
天津理工大学青年教师科研育苗基金项目,项目编号:LGYM201005. （）
