摘要
Abstract
Objective To investigate the therapeutic efficacy and safety of oxaliplatin combined with capecitabine in the treatment of patients with advanced rectal cancer. Methods A hundred and fourteen patients with advanced rectal cancer admitted to the oncology department of this hospital from September 2005 to December 2009 were given oxaliplatin combined with capecitabine, and the concrete regimen was oxaliplatin 120 mg/m2 by intravenous drip for 2 h on t d, oral capecitabine 2 500 mg/m2, twice daily, from 1 d to 14 d, with 21 d as a cycle of treatment. All patients received at least 2 cycles and were followed up for 2 years after treatment. Results Among 114 cases of advanced rectal cancer, 46 cases had partial remission, 43 cases had stable disease, 25 cases had disease progression, with the total effective rate of 40.35%. The one - year - survival rate was 55. 26% (63/114), and the two-year-survival rate was 21.93% (25/114). The major adverse reactions included neurotoxicity, hand - foot syndrome, gastrointestinal adverse reaction, myelosuppression, etc, and their classification was not too serious and mainly degree I and degree II. Conclusion Oxaliplatin combined with capecitabine has good efficacy in the treatment of advanced rectal cancer with mild adverse reactions.关键词
奥沙利铂/卡培他滨/晚期直肠癌Key words
oxaliplatin/ capecitabine/ advanced rectal cancer分类
医药卫生
