摘要
Abstract
Objective To investigate the effect of enalapril in treating early diabetic nephropathy. Methods Sixty - five patients with type 2 diabetes mellitus(T2DM) complicating early diabetic nephropathy were randomly divided into the observation group(33 cases) and the control group(32 cases). Two groups were given the routine comprehensive treatment, including lowering blood glucose, essential amino acids, diuretic and low salt, high - quality low - protein diet. The observation group was added Enalapril Maleate Tablet on the base of the conventional therapy. Both the two groups were treated for continuous 12 weeks. Blood pressure was monitored in the two groups, Fasting blood glucose (FPG),2h postprandial blood glucose (2 h PBG), blood urea nitrogen (BUN), creatinine (Scr), endogenous creatinine clearance rate (Ccr) were detected. The immune turbidimetric assay was adopted to determine urine albumin (u - ALB) and the microparticle enzyme immunoassay assay was used to detect β2 microglobulin (β2 - MG). Results The improvement degree of FPG, 2 h PBG, Scr and Ccr after treatment in the observation group were significantly superior to the control group ( P < 0. 05). The u-ALB and β2 - MG levels in the observation group were significantly decreased ( P <0. 05 or P<0. 01). Conclusion Enalapril significantly decreases the u - ALB and β2 - MG levels in early diabetic nephropathy and helps to protect the renal function and delay the progress of diabetic nephropathy.关键词
糖尿病肾病/尿微量白蛋白/β2微球蛋白/依那普利Key words
diabetic nephropathy/ urinary albumin/ β2 microglobulin/ enalapril分类
医药卫生
