中华医学杂志（英文版）2012，Vol.125Issue(18)：3279-3282,4.DOI:10.3760/cma.j.issn.0366-6999.2012.18.015
Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions: a tissue microarray study
Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions: a tissue microarray study
ZHAO Yan 1QIAO Zheng-guo 2SHAN Shi-jun 3SUN Qing-miao 1ZHANG Jian-zhong1
作者信息
- 1. Department of Dermatology, Peking University People's Hospital, Beijing 100044, China
- 2. Department of Central Laboratory , Peking University People's Hospital, Beijing 100044, China
- 3. Department of Dermatology, Tianjin Medical University General Hospital, Tianjin 300052, China
- 折叠
摘要
Abstract
Background Glycoprotein non-metastatic melanoma protein B (GPNMB) plays an important role in the pathogenesis of inflammatory and malignant diseases.We investigated the expression of GPNMB in benign and malignant skin diseases.Methods Tissue microarray was performed in the skin tissues of 102 cases including malignant melanoma (MM),squamous cell carcinoma (SCC),basal cell carcinoma (BCC),and benign dermatosis.The expression of GPNMB in the tissues was detected by immunohistochemistry.Twenty cases of normal skin and adjacent neoplastic normal skin tissues were selected as controls.Results GPNMB was positively stained in skin malignancies (38/50,76％),which was significantly higher than that in the control and the benign skin tissues (P=0.001 and ＜0.001 respectively).GPNMB was positively stained in MM (13/15,87％) and SCC (16/20,80％) (P ＜0.001).Significant higher expression of GPNMB was observed in patients aged ≥65years than those less than 65 years (n=11 and n=9 respectively,P=0.027).No significant difference of the expression rates was observed between normal control and BCC; however,stronger intensity was detected in the latter.Negative or weak expression was observed in the controls.Conclusion Over-expression of GPNMB correlated strongly and might play an important role in the pathogenesis of MM and SCC.关键词
glycoprotein non-metastatic melanoma protein B/skin tumor/tissue microarrayKey words
glycoprotein non-metastatic melanoma protein B/skin tumor/tissue microarray引用本文复制引用
ZHAO Yan,QIAO Zheng-guo,SHAN Shi-jun,SUN Qing-miao,ZHANG Jian-zhong..Expression of glycoprotein non-metastatic melanoma protein B in cutaneous malignant and benign lesions: a tissue microarray study[J].中华医学杂志（英文版）,2012,125(18):3279-3282,4.
