中华医学杂志（英文版）2012，Vol.125Issue(18)：3318-3324,7.DOI:10.3760/cma.j.issn.0366-6999.2012.18.022
Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells
Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells
LIU Bo-wu 1AI Shi-yi 1L(U) An-lin 1HOU Jing 1HUANG Wei 1LI Yao 1HOU Zhao-lei 1HOU Hong 1DA Jing 1YANG Na1
作者信息
- 1. Department of Cardiology, Xijing Hospital, Fourth Military Medical University of Chinese People's Liberation Army, Xi'an,Shaanxi 710032, China
- 折叠
摘要
Abstract
Objective To review the progress of cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells.Data sources The databases of PubMed,Springer Link,Science Direct and CNKI were retrieved for papers published from January 2000 to January 2012 with the key words of “bone marrow mesenchymal stem cells,cardiac or heart,electrophysiology or electrophysiological characteristics”.Study selection The articles concerned cardiac differentiation and electrophysiological characteristics of bone marrow mesenchymal stem cells were collected.After excluding papers that study purposes are not coincident with this review or contents duplicated,56 papers were internalized at last.Results For the treatment of myocardial infarction and myocardiac disease,the therapeutic effects of transplantation of bone marrow mesenchymal stem cells which have the ability to develop into functional myocardial cells by lots of methods have been proved by many researches.But the arrhythmogenic effect on ventricles affer transplantation of bone marrow mesenchymal stem cells derived myocardial cells is still controversial in animal models.Certainly,the low differentiation efficiency and heterogeneous development of electricial function could be the most important risk for proarrhythmia.Conclusion Many studies of cardiac differentiation of bone marrow mesenchymal stem cells have paid attention to improve the cardiac differentiation rate,and the electrophysiology characteristics of the differentiated cells should be concerned for the risk for proarrhythmia as well.关键词
mesenchymal stem cell/differentiation/cardiac electrophysiologyKey words
mesenchymal stem cell/differentiation/cardiac electrophysiology引用本文复制引用
LIU Bo-wu,AI Shi-yi,L(U) An-lin,HOU Jing,HUANG Wei,LI Yao,HOU Zhao-lei,HOU Hong,DA Jing,YANG Na..Cardiac differentiation and electrophysiology characteristics of bone marrow mesenchymal stem cells[J].中华医学杂志（英文版）,2012,125(18):3318-3324,7.
